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  • Pathology Outlines - HCC - scirrhous type
    Scirrhous hepatocellular carcinoma (see comment) Comment: This tumor shows histologic features of scirrhous hepatocellular carcinoma with nests and trabecula of hepatoid cells within a dense fibrous stroma The tumor cells show positive staining for glypican 3, arginase1 and CK7, as is typical for this variant
  • Invasive breast cancer of no special type (NST)
    Tumors characterized by small cancer nests accompanied by marked fibrosis (desmoplastic scirrhous); this type diffusely infiltrates the surrounding tissue as an irregular shaped spiculated mass Calcification in 60% of cases, variable necrosis Elastosis involves stroma, wall of vessels and ducts and causes grossly noted chalky streaks
  • Pathology Outlines - WHO classification
    Hepatocellular carcinoma, scirrhous 8172 3; Hepatocellular carcinoma, clear cell type 8174 3; Hepatocellular carcinoma, steatohepatitic Hepatocellular carcinoma, macrotrabecular massive; Hepatocellular carcinoma, chromophobe Hepatocellular carcinoma, neutrophil rich Hepatocellular carcinoma, lymphocyte rich Hepatoblastoma, NOS 8970 3
  • Pathology Outlines - Hepatocellular carcinoma overview
    Glypican 3: cytoplasmic; high sensitivity in poorly differentiated and scirrhous hepatocellular carcinoma but low sensitivity in well differentiated hepatocellular carcinoma (nonneoplastic liver is negative) AFP: cytoplasmic; highly specific but low sensitivity; frequently negative in well differentiated hepatocellular carcinoma
  • WHO classification - Pathology Outlines
    A Good prognosis, ER PR negative, HER2 negative Tall cell carcinoma with reversed polarity (TCCPR) is a rare subtype of invasive breast carcinoma characterized by tall columnar cells with reversed nuclear polarity, arranged in solid and solid papillary patterns and most commonly associated with IDH2 p Arg172 hotspot mutations
  • Pathology Outlines - Staging-hepatocellular carcinoma
    AJCC 7th edition staging was sunset on December 31, 2017; as of January 1, 2018, use of the 8th edition is mandatory (Amin: AJCC Cancer Staging Manual, 8th Edition, 2018)
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    Moved Permanently The document has moved here
  • Pathology Outlines - Diffuse type
    Stomach - Diffuse (poorly cohesive) type adenocarcinoma Incidence of diffuse type gastric adenocarcinoma is increasing worldwide but is slightly less than intestinal type (Eur J Cancer 2020;130:23)
  • Pathology Outlines - High grade serous carcinoma
    Ovary - High grade serous carcinoma 13 year old girl and 69 year old woman with normal sized ovarian carcinoma syndrome (Horm Mol Biol Clin Investig 2018;35:1)
  • Pathology Outlines - HCC - cytology
    Glypican 3 (GPC3): cytoplasmic; high sensitivity in poorly differentiated and scirrhous hepatocellular carcinoma, low sensitivity in well differentiated hepatocellular carcinoma, negative in benign and nonneoplastic liver (Diagn Cytopathol 2009;37:629, Pathol Oncol Res 2015;21:379)





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