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microglia    
小神经胶质; 格子细胞

小神经胶质; 格子细胞


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  • A neurodegenerative cellular stress response linked to dark microglia . . .
    Second, the lack of difference in global translation levels in DAM compared to homeostatic microglia, despite the increase in eIF2α-P in DAM, is unexpected This might suggest that, although somewhat elevated in relation to control microglia, eIF2α-P in DAM is not sufficient to cause a global arrest of translation
  • Microglia Build Plaques to Protect the Brain - ALZFORUM
    Microglia do not express the third TAM member, Tyro3, which is predominantly found in neurons The receptors have been linked previously to Alzheimer’s disease and amyloidosis For example, Lemke and colleagues reported that microglia around plaques modestly boost Mer expression and massively upregulate Axl (Jul 2019 conference news) Super Star
  • Delivery Courier? Microglia Drop Neprilysin Off Near Plaques in Brain
    When microglia encounter amyloid plaques, they express a particular set of genes Specifically, in microglia that are close to a plaque, the promoter CD9 turns on this known plaque-responsive signature But if the cells move just a few microns away, CD9 is completely off “It’s almost like this binary genetic switch,” said Chadarevian
  • Do Rod-Shaped Microglia Dampen Hyperexcitability in ALS?
    However, it is still unknown whether the Lgals3 + rod-shaped microglia, detected using immunohistochemistry in this study, truly represent microglia or if they are infiltrating macrophages Moreover, since global TREM2-KO mice were used in this study, it is possible that the observed effect is due to deletion of TREM2 in peripheral myeloid cells
  • Circulating Monocytes Replace Microglia, Border-Associated Macrophages
    Microglia Multitudes Monocyte-derived microglia (Mo-Mglia) of diverse origins express different gene sets, giving them unique signatures Only fetal liver monocyte-derived microglia expressed the obligate microglial marker Sall1 “These findings are important because they fill in many gaps in our understanding of myeloid cell fate potential
  • Harnessing human iPSC-microglia for CNS-wide delivery of disease . . .
    Replacing endogenous microglia with genetically modified microglia to deliver therapeutics could be a game-changer in the treatment of brain disorders I’m actively working on microglia transplantation myself so I wasn’t surprised by the concept, but there’s a big difference between expecting a certain outcome and actually doing the hard
  • Expunging Microglial Lipid Droplets Boosts Phagocytosis
    By 6 months, lipid staining revealed that microglia in these mice had 30 percent smaller lipid droplet area than control microglia The FIT2-deficient microglia were not entirely devoid of droplets, in keeping with the protein primarily unleashing triglyceride-laden droplets Other lipids, such as sterol esters, may still contribute
  • Microglia protect against age-associated brain pathologies . . . - ALZFORUM
    Both papers agree that the lack of microglia in adult mice results in neurodegeneration, brain calcifications, and myelin abnormalities, phenotypes resembling CSF1R-related leukoencephalopathy Transplantation of wild-type mouse human microglia rescued these phenotypes and protected against the development of the associated pathologies
  • Ferried Into Brain, TREM2 Antibody Stirs Microglia
    ATV:TREM2 increased the number of proliferating microglia as measured by uptake of the modified nucleoside EdU When taken out of the mice, these microglia engulfed more fluorescently labeled Aβ and myelin than microglia from mice given a control antibody They also upregulated genes involved in oxidative phosphorylation and glycolysis
  • Part with PILRA, Power Up Microglia? - ALZFORUM
    Because lipid-accumulating microglia (LAMs) emerge in aging brains and around amyloid plaques, the scientists wanted to know more (Aug 2019 news) They found that, sans PILRA, microglia dialed down expression of transporters that shuttle lipids out of the cell, such as ABCA1 and ABCG1, and that they imbibed more ApoE





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