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  • Transthyretin - Wikipedia
    Transthyretin (TTR or TBPA) is a transport protein in the plasma and cerebrospinal fluid that transports the thyroid hormone thyroxine (T 4) and retinol to the liver This is how transthyretin gained its name: trans ports thy roxine and retin ol
  • Transthyretin Amyloidosis (ATTR-CM): Types, Causes, Treatment
    Transthyretin amyloidosis (ATTR-CM) occurs when your liver produces faulty transthyretin (TTR) proteins Clumps of these abnormal proteins (called fibrils) build up in your heart’s main pumping chamber
  • A Narrative Review of the Role of Transthyretin in Health and . . .
    Transthyretin is a highly conserved protein that transports the thyroid hormone thyroxine and the retinol-binding protein bound to retinol (vitamin A) Mutations in TTR are associated with ATTR amyloidosis, a progressive, debilitating, and ultimately fatal disease
  • Transthyretin Amyloid Cardiomyopathy (ATTR-CM) | American . . .
    Transthyretin (trans-thy-re-tin) amyloid cardiomyopathy (ATTR-CM) is an underdiagnosed and potentially fatal disease of the heart muscle In ATTR-CM, a protein called transthyretin that normally circulates in the bloodstream becomes misshapen and builds up in the heart, nerves and other organs
  • The role of transthyretin in cell biology: impact on human . . .
    Transthyretin (TTR) is an extracellular protein mainly produced in the liver and choroid plexus, with a well-stablished role in the transport of thyroxin and retinol throughout the body and brain
  • Transthyretin: Its function and amyloid formation - ScienceDirect
    Transthyretin (TTR), one of the major amyloidogenic proteins in systemic amyloidosis, is mainly synthesized in the liver but also in the choroid plexuses of the brain (Bezerra et al , 2020)
  • Transthyretin | Neurology
    Plasma transthyretin (TTR, formerly called prealbumin) is a 55-kd protein that participates in the plasma transport of both thyroxine and retinol (vitamin A) TTR concentrations are disproportionately high in human ventricular CSF, suggesting that TTR is either selectively transported across or synthesized de novo within the blood-CSF barrier
  • Cardiac transthyretin amyloidosis treatment improves outcomes . . .
    Concomitant aortic stenosis (AS) and transthyretin-associated cardiac amyloidosis (ATTR-CA) is an increasingly recognized cause of structural heart failure Aortic valve replacement (AVR) improves prognosis in this population, but the efficacy of ATTR-specific medication remains unclear





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