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  • Should we treat pyrexia? And how do we do it? - Critical Care
    The concept of pyrexia as a protective physiological response to aid in host defence has been challenged with the awareness of the severe metabolic stress induced by pyrexia The host response to pyrexia varies, however, according to the disease profile and severity and, as such, the management of pyrexia should differ; for example, temperature control is safe and effective in septic shock but
  • Pyrexia: aetiology in the ICU | Critical Care | Full Text
    Most episodes of pyrexia are due to infections, but incidence estimates of infectious and noninfectious aetiologies are limited by studies with small sample size and inconsistent reporting of noninfectious aetiologies Pyrexia commonly triggers a full septic work-up, but on its own is a poor predictor of culture-positivity
  • The pathophysiological basis and consequences of fever
    The evidence is that in sepsis the beneficial effects of pyrexia may balance these deleterious factors However, in non-sepsis, the accumulation of the deleterious consequences of hyperthermia occurs early, at even mild degrees of fever Hyperthermia above 40 °C appears to carry a high mortality by whatever cause
  • The pathophysiological basis and consequences of fever
    The evidence is that in sepsis the beneficial effects of pyrexia may balance these deleteri-ous factors However, in non-sepsis, the accumulation of the deleterious consequences of hyperthermia occurs early, at even mild degrees of fever Hyperthermia above 40 °C appears to carry a high mortality by whatever cause
  • Pyrexia: aetiology in the ICU - BioMed Central
    Pyrexia, also referred to as fever, is an adaptive response to a physiologic stress that is tightly regulated through endogenous pyrogenic and anti-pyretic pathways, and is associated with an increase in the hypothalamic set point [18]
  • Should we treat pyrexia? And how do we do it?
    Abstract The concept of pyrexia as a protective physiological response to aid in host defence has been challenged with the awareness of the severe metabolic stress induced by pyrexia The host response to pyrexia varies, however, according to the disease profile and severity and, as such, the management of pyrexia should differ; for example, temperature control is safe and effective in septic
  • Targeted temperature control following traumatic brain injury: ESICM . . .
    Aims and scope The aim of this panel was to develop consensus recommendations on targeted temperature control (TTC) in patients with severe traumatic brain injury (TBI) and in patients with moderate TBI who deteriorate and require admission to the intensive care unit for intracranial pressure (ICP) management Methods A group of 18 international neuro-intensive care experts in the acute
  • Fever and hypothermia represent two populations of sepsis patients and . . .
    Background Fever and hypothermia have been observed in septic patients Their influence on prognosis is subject to ongoing debates Methods We did a secondary analysis of a large clinical dataset from a quality improvement trial A binary logistic regression model was calculated to assess the association of the thermal response with outcome and a multinomial regression model to assess factors
  • Effect of Calotropis procera latex extracts on the hypothalamic TNFα . . .
    AqDL and MeDL are orally effective, LP is effective parenterally The current study was designed to evaluate the efficacy of these extracts against yeast-induced pyrexia and the levels of TNFα and PGE 2 in the hypothalamus of rats
  • Temperature control after cardiac arrest - Critical Care
    Most of the patients who die after cardiac arrest do so because of hypoxic-ischemic brain injury (HIBI) Experimental evidence shows that temperature control targeted at hypothermia mitigates HIBI In 2002, one randomized trial and one quasi-randomized trial showed that temperature control targeted at 32–34 °C improved neurological outcome and mortality in patients who are comatose after





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