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  • Adhere, Degrade, and Move: the three-step model of invasion
    Experimental work during the period 1975–1986 revealed the crucial importance of the extracellular matrix (ECM) in tumor cell invasion and metastasis, and culminated in the three-step hypothesis of invasion (1) The first step is tumor cell attachment to the ECM
  • Tumor Invasion and Metastasis Flashcards - Quizlet
    Three-step theory of tumor invasion -events occur after tumor cells detach -Three major steps- sequence of events 1 tumor cell attachment to matrix -Extracellular matrix 2 Degradation of matrix 3 Locomotion into matrix
  • Molecular Aspects of Tumor Cell Invasion and Metastasis
    Figure 1 Three-step hypothesis of invasion As depicted for a tumor cell exiting a capillary, the first step is attachment of the tumor cell to the subendothelial basement membrane This is followed by secretion and activation of proteinases, including matrix metalloproteinases that cleave extracellular matrix components
  • Chapter 32 invasion and metastasis | PPT - SlideShare
    The key steps of ECM invasion are: 1) changes in cell adhesion, 2) degradation of the ECM, 3) attachment to novel ECM components, and 4) migration of tumor cells through active proteolysis and locomotion
  • Tumor Invasion and Metastasis - ppt download - SlidePlayer
    6 Three-Step Theory of Invasion Tumor cell attachment Fibronectin and laminin Degradation or dissolution of the matrix Enzymes Locomotion into the matrix Invadopodia 7 Metastasis Spread of cancer from a primary site of origin to a distant site Steps Direct or continuous extension Penetration into lymphatics, blood
  • Unit III: Cell Proliferation: Cancer Cancer - Mercer County Community . . .
    3 Bacterial Cause of Cancer • Helicobacter pylori –Chronic infections are associated with: •Peptic ulcer disease •Stomach carcinoma •Mucosa-associated lymphoid tissue lymphomas Inflammation and Cancer • Chronic inflammation is an important factor in development of cancer –Cytokine release from inflammatory cells –Free radicals
  • Molecular events that take place during cell invasion: three-step . . .
    Repetition of these steps results in cellular invasion The extracellular matrix (ECM) holds cells together and maintains the three-dimensional structure of the body It also plays critical
  • Adhere, Degrade, and Move: The Three-Step Model of Invasion
    The first step is tumor cell attachment to the ECM The second step is proteolytic degradation of the ECM, led by advancing protruding actin-rich pseudopods The third step is migration of the tumor cell body through the remodeled matrix
  • Matrix Metalloproteinases in Cancer | SpringerLink
    The “three step theory of invasion” proposed by Liotta and colleagues (1) suggests that potentially invasive cells must first attach to basement membrane proteins via cell-surface receptors, i e , the integrins Localized, extracellular proteolytic activity then clears a path for the cell
  • Cancer Growth Flashcards - Quizlet
    What is included in the three-step theory of invasion? what are the steps in metastasis? •Growth of cancerous colonies depends on an adequate blood supply •often occurs in the first capillary bed encountered by circulating cells -Many epithelial-like characteristics (e g , polarity, adhesion to basement membrane) are lost





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