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  • A guide to adaptive immune memory | Nature Reviews Immunology
    Immune memory — comprising T cells, B cells and plasma cells and their secreted antibodies — is crucial for human survival It enables the rapid and effective clearance of a pathogen after re
  • MECHANISMS OF MEMORY T CELL ACTIVATION AND EFFECTIVE IMMUNITY
    Formation of long-lasting antigen-specific memory CD8 + T cells involves complex sets of events that comprise initial activation (priming), proliferation (expansion) and massive apoptosis (contraction), after which the cells that survive give rise to long-lived memory cells (Cui and Kaech, 2010; Harty and Badovinac, 2008; McKinstry et al , 2010
  • Immunological memory - Immunobiology - NCBI Bookshelf
    Memory T-cell responses have been harder to study, but can also be distinguished from the responses of naive or effector T cells The principal focus of this section will be the altered character of memory responses, although we will also discuss emerging explanations of how immunological memory persists after exposure to antigen
  • Immunology Chapter 11: Immunological Memory and Vaccination
    2 Ensure that future invasions by the pathogen will be met by an immune response of overwhelming force Mediating such secondary immune responses are long-lived pathogen-specific memory T cells and Memory B-cells
  • T Cell Memory in Infection, Cancer, and Autoimmunity
    The generation and distribution of each of these memory T cell subsets obey highly diverse epigenetic, transcriptional and proteome pathways (2, 19, 23, 31–33) The studies on genome-wide transcriptional and epigenetic changes (by using the assay for transposase-accessible chromatin with sequencing during infection or vaccination showed that DNA methylation, histone modifications, and
  • Keeping T cell memories in mind - Cell Press
    T cells provide cell-mediated immunity by recognizing and responding to presented peptides in the settings of infection and cancer [1] Naïve T cells (see Glossary) lack the machinery to enter and embed in tissues, whereas antigen-experienced memory T cells have long been appreciated in the human CNS [2] Recent advances in neuroimmunology, including the rediscovery of the meningeal lymphatic
  • Memories that last: Dynamics of memory T cells throughout the . . .
    Future studies into the dynamics of antigen-specific memory T cells, varying from those that are continuously exposed to their antigen to those whose antigen is no longer present, are needed to gain better insight into how desired long-term memory T-cell responses against pathogens and undesired memory T-cell responses against self-antigens are





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