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  • Immune Checkpoint Inhibitors - NCI - National Cancer Institute
    Immunotherapy drugs called immune checkpoint inhibitors work by blocking checkpoint proteins from binding with their partner proteins This prevents the “off” signal from being sent, allowing the T cells to kill cancer cells One such drug acts against a checkpoint protein called CTLA-4
  • Immune checkpoint signaling and cancer immunotherapy
    Immune checkpoint blockade therapy has become a major weapon in fighting cancer Antibody drugs, such as anti-PD-1 and anti-PD-L1, demonstrate obvious advantages such as broad applicability
  • Checkpoint Blockade Immunotherapy | Moffitt
    Checkpoint blockade immunotherapy is an innovative treatment that uses medications known as immune checkpoint inhibitors to address several types of cancer
  • Cancer immunotherapy using checkpoint blockade - PubMed
    The release of negative regulators of immune activation (immune checkpoints) that limit antitumor responses has resulted in unprecedented rates of long-lasting tumor responses in patients with a variety of cancers
  • Our Current Understanding of Checkpoint Inhibitor Therapy in . . .
    The checkpoint blockade (a blockade of immune checkpoint inhibitory pathways activated by cancer cells) has been developed as one of the approaches in cancer immunotherapy to reactivate anti-tumor immune response 9 For example, during the priming phase, naïve T cells in the lymphoid organs become exposed to tumor-specific antigens, resulting
  • Immune Checkpoint Inhibitor Cancer Treatment | Memorial Sloan . . .
    Checkpoint inhibitors work by releasing a natural brake on your immune system so that immune cells called T cells recognize and attack tumors This therapy is sometimes called immune checkpoint blockade because the molecule that acts as a brake on immune cells — the checkpoint — is blocked by the drug
  • Neoadjuvant checkpoint blockade for cancer immunotherapy - AAAS
    Checkpoint blockade immunotherapy using antibodies that inhibit the programmed cell death 1 (PD-1) or cytotoxic T lymphocyte–associated protein 4 (CTLA-4) pathways has resulted in unprecedented clinical outcomes for certain cancers such as melanoma
  • Targeted CD47 checkpoint blockade using a mesothelin-directed . . .
    Blocking the CD47–SIRPα axis is a promising immunotherapeutic strategy against cancer However, early trial data has demonstrated on-target off-leukemia toxicity In addition, the ubiquitous expression pattern of CD47 might contribute to an antigen sink
  • Immune Checkpoint Blockade Therapies for Colorectal Cancer . . .
    Current treatments focus on targeting inhibiting PD-1 and cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) pathways with antibodies, such as pembrolizumab, nivolumab, and ipilimumab Meanwhile, there are numerous novel immunotherapeutic approaches being investigated
  • The blockade of immune checkpoints in cancer immunotherapy
    Multiple additional immune-checkpoint receptors and ligands, some of which are selectively upregulated in various types of tumour cells, are prime targets for blockade, particularly in





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