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  • Womens Health Initiative
    The Women’s Health Initiative is a landmark study that has had a huge impact on medical practice and public health — Gary H Gibbons, M D , NHLBI Director 2,572 papers published using WHI data
  • About WHI
    The Women’s Health Initiative (WHI) is a long-term national health study funded by the National Heart, Lung, and Blood Institute, or NHLBI The original WHI study began in the early 1990s and concluded in 2005 Since 2005, the WHI has continued as Extension Studies, which are annual collections of health updates and outcomes in active participants The second Extension Study enrolled 93,500
  • Main Findings from the WHI Trials:
    The Women’s Health Initiative Randomized Controlled Trial JAMA 2004; 291: 1701-1712 Follow-up through 2010: Manson JE, Chlebowski RT, Stefanick ML, et al Menopausal Hormone Therapy and Health Outcomes During the Intervention and Extended Poststopping Phases of the Women’s Health Initiative Randomized Trials
  • WHI Publications
    Aging is the strongest risk factor for dementia; however, few studies have examined the association of biological aging with incident dementia We analyzed 6069 cognitively unimpaired women (mean age = 70 0 ± 3 8 years) in the Women's Health Initiative Memory Study to examine the association of accelerated biological aging, measured with second and third-generation epigenetic clocks
  • Ancillary Studies - WHI
    Women’s Health Initiative Sleep Hypoxia Effects on Resilience – WHISPER The WHISPER study examines whether sleep-disordered breathing and the resulting low blood oxygen are associated with increased risks of health events, including heart attack, stroke, heart failure, cancer, and cognitive decline Study details
  • Womens Health Initiative
    Endogenous sex hormones, sex hormone-binding globulin, and muscle health: insights into sarcopenia and sarcopenic obesity from the Women's Health Initiative Amar Osmancevic et al , 2026 2 PubMed # 41701631
  • About the WHI - whi. org
    About the WHI Design Protocol The Women’s Health Initiative consists of two major parts: a set of randomized Clinical Trials and an Observational Study The WHI Clinical Trials (CT) (n=68,132) includes three overlapping components, each a randomized controlled comparison among women who were postmenopausal and aged 50-79 at randomization
  • News from the WHI Study
    Today, Women’s Health Initiative (WHI) investigators were informed that the Department of Health and Human Services (HHS) will terminate WHI Regional Center (RC) contracts at the end of their current fiscal year (September 2025)


















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