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  • Huntingtin - Wikipedia
    Huntingtin (Htt) is the protein coded for in humans by the HTT gene, also known as the IT15 ("interesting transcript 15") gene [5] Mutated HTT is the cause of Huntington's disease (HD), and has been investigated for this role and also for its involvement in long-term memory storage
  • Targeting Huntingtin Expression in Patients with Huntington’s Disease
    IONIS-HTT Rx (hereafter, HTT Rx) is an antisense oligonucleotide designed to inhibit HTT messenger RNA and thereby reduce concentrations of mutant huntingtin We conducted a randomized,
  • New Understanding of How Genetic Mutation Causes Huntington’s Disease
    For 30 years, researchers have known that Huntington’s disease is caused by an inherited mutation in the Huntingtin (HTT) gene in which a three-letter DNA sequence, C-A-G, is repeated at least 40 times
  • HTT huntingtin [Homo sapiens (human)] - Gene - NCBI
    Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product
  • Huntingtin and the molecular pathogenesis of Huntingtons disease
    Huntington's disease (HD) is a late-onset neurodegenerative disorder that is caused by a CAG repeat expansion in the IT15 gene, which results in a long stretch of polyglutamine close to the amino-terminus of the HD protein huntingtin (htt)
  • Huntington Disease | Learn Science at Scitable - Nature
    HD is a rare, adult-onset, autosomal dominant, progressive neurodegenerative disease George Huntington (Figure 1) was the first person to provide a comprehensive description of adult-onset HD
  • HTT Gene - GeneCards | HD Protein | HD Antibody
    HTT (Huntingtin) is a Protein Coding gene Diseases associated with HTT include Huntington Disease and Lopes-Maciel-Rodan Syndrome Among its related pathways are Gene expression (Transcription) and Transcriptional Regulation by MECP2
  • HTT Gene | Huntingtons Victoria
    The HTT gene, located on Chromosome 4, provides instructions for producing a vital protein called huntingtin While the precise role of this protein remains unclear, it holds significance in nerve cells (neurons) within the brain and is crucial for normal development before birth


















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