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  • Factors Affecting the Absorption of Subcutaneously . . .
    Consequently, lipohypertrophy is associated with delayed insulin absorption, reduced bioavailability (potentially due to a higher degree of local degradation), and increased pharmacokinetic variability between injections [137, 138, 168]
  • Factors Affecting the Absorption of Subcutaneously . . .
    Since this variability is largely inuenced by the absorption of insulin, a deeper fl understanding of the factors a ffecting the absorption of insulin from the subcutaneous tissue is necessary in order to improve glycaemic control and the long-term prognosis in people with diabetes
  • Pharmacokinetics of local anaesthetics - ScienceDirect
    The decreased vascularity and the presence of varying amounts of adipose tissue in the region of the brachial plexus and subcutaneous tissue may account for the rather slow absorption of local anaesthetics in these areas
  • Factors Affecting the Absorption of Subcutaneously . . . - PubMed
    Since this variability is largely influenced by the absorption of insulin, a deeper understanding of the factors affecting the absorption of insulin from the subcutaneous tissue is necessary in order to improve glycaemic control and the long-term prognosis in people with diabetes
  • Modeling Between-Subject Variability in Subcutaneous . . .
    Here, we aimed to apply the NLME modeling technique to such a model in order to describe the BSV present in the pharmacokinetics of subcutaneous absorption of lispro, a fast-acting insulin analogue In doing so, we tried also to personalize the model by the use of subject covariates
  • Factors affecting drug absorption and distribution
    There are four elements to pharmacoki-netics: absorption, distribution, metabolism, and excretion Drug ab-sorption involves the movement of the drug across a cell membrane and is largely dependent on diffusion
  • Visualisation and quantification of subcutaneous injections . . .
    Five repeats for four injection conditions allow for the first time an assessment of the effects of injection site variability on injectate dispersion and tissue backpressure The relevance of this variability to clinical PK studies is discussed in terms of transit distance to lymph vessels





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