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  • Anticoagulation Management: Current Landscape and Future Trends
    Emerging trends include the development of factor XIa inhibitors, which promise more targeted thrombosis prevention with potentially lower bleeding risks This review highlights the ongoing innovation in anticoagulant development, the need for precise management, and potential future avenues like factor XIa inhibitors
  • Venous Thromboembolism: Role of the Clinical Laboratory in . . .
    Performing testing at a time of acute attack or during ongoing anticoagulant treatment may confound laboratory results, often leading to false-positive or false-negative test results because (a) active thrombosis can decrease levels of antithrombin, protein C, and protein S, (b) heparin therapy can decrease antithrombin levels, and (c) warfarin
  • Thrombophilia testing in the era of direct oral anticoagulants
    DOACs have been shown to affect the clotting assays used to test for thrombophilias, 1–3 especially those used to test for APS 3 However, these tests results appear accurate at DOAC trough levels 19 – suggesting that anticoagulated patients could still be tested for a thrombophilia at the DOAC trough 3
  • How I treat unexplained arterial thrombosis Free
    The workup and management of unexplained arterial thrombosis is complex because of the multiple potential contributors to arterial thrombotic risk and the lack of data on recommended diagnostic evaluation, thrombosis recurrence risk, and best management
  • Management of bleeding risk in patients who receive . . .
    This report of the ISTH subcommittee on Predictive and Diagnostic Variables in Thrombotic Disease summarizes the evidence on the prediction of bleeding in VTE patients We systematically searched the literature and identified 34 original studies evaluating either predictors or risk prediction models for prediction of bleeding risk on
  • The postthrombotic syndrome: current evidence and future . . .
    Proximal DVT and recurrent ipsilateral DVT are the two principal established risk factors for PTS, and efforts in recent years have been focused on identifying a combination of clinical and biomarker predictors that will define high-risk patients and possibly new therapeutic targets
  • Clinical Manifestations, Current and Future Therapy, and Long . . .
    Our recent study suggests that the current volumes of FFP infusions are insufficient to prevent frequent thrombotic events and long-term ischemic organ damage This review focuses on the current management of cTTP and its associated issues, followed by the importance of upcoming recombinant ADAMTS13 therapy





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