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  • PRAME Expression in Melanocytic Tumors - PMC - PubMed Central (PMC)
    PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen that was isolated by autologous T cells in a melanoma patient While frequent PRAME mRNA expression is well documented in cutaneous and ocular melanomas, little is
  • PRAME - Wikipedia
    PRAME (preferentially expressed antigen of melanoma) is a protein that in humans is encoded by the PRAME gene [3] [4] [5] Five alternatively spliced transcript variants encoding the same protein have been observed for this gene [5]
  • PRAME Expression in Cancer. A Systematic Immunohistochemical Study of . . .
    Preferentially expressed antigen in melanoma (PRAME) is considered a useful marker in the differential diagnosis between malignant melanoma and its melanocytic mimics Recently PRAME expression was documented in nonmelanocytic tumors, but much of the data are based on mRNA studies
  • PRAME – MyPathologyReport
    PRAME stands for “preferentially expressed antigen in melanoma ” It is a special type of protein called a cancer-testis antigen This means that PRAME is usually found in cancer cells and normal cells within the testis, but rarely in other normal tissues of the body
  • PRAME Updated: Diagnostic, Prognostic, and Therapeutic Role in . . . - MDPI
    PRAME is a nuclear receptor, a transcriptional regulator, and a member of the cancer testis antigen (CTA) family of proteins It is situated on the reverse strand of chromosome 22 (22q11 22), within the human immunoglobulin lambda gene locus
  • PRAME Shows Promise as a Treatment Avenue in Melanoma, Other . . . - OncLive
    As investigators continue to refine and carve out a role for targeted therapies in the treatment paradigm across tumor types, preferentially expressed antigen in melanoma (PRAME) has emerged
  • The Role of PRAME in Malignant Melanoma: From Biomarker to Therapeutic . . .
    PRAME, initially identified as a melanoma-associated antigen [1], has garnered attention for its implications in cancer progression and therapeutic intervention This review aims to delineate PRAME’s multifaceted roles in malignant melanoma and its implications for clinical management
  • How Useful Is PRAME Testing in Choroidal Melanoma?
    Preferentially expressed antigen in melanoma, or PRAME, is a cancer-test antigen that is overexpressed in melanoma and is typically a marker of poor outcomes Up first, Zélia M Corrêa, MD, PhD, explained why she favors testing for PRAME Improved prognostic testing accuracy
  • Use of PRAME immunostaining to distinguish early melanoma in situ from . . .
    PRAME immunohistochemistry has proven effective in distinguishing melanocytic nevi from melanoma, but it is unclear if it may be used to distinguish melanoma in situ from other benign pigmented lesions
  • PRAME Expression: A Target for Cancer Immunotherapy and a Prognostic . . .
    Preferentially Expressed Antigen in Melanoma (PRAME) is a cancer testis antigen, expressed in the testis, but also in cancers, including uveal melanoma PRAME is considered a target for immune therapy in several cancers, and PRAME-specific T cell clones have been shown to kill UM cells





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