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  • Thrombolysis for Ischemic Stroke Beyond the 4. 5-Hour Window: A Meta . . .
    Background: A minority of patients with stroke qualify for intravenous thrombolysis (IVT) within 4 5-hour window The safety and efficacy of IVT beyond this period have not been well studied Methods: We systematically searched MEDLINE, Embase, Cochrane, and ClinicalTrials gov for relevant randomized clinical trials Randomized clinical trials comparing IVT versus standard medical care in
  • Thrombolysis for Ischemic Stroke Beyond the 4. 5-Hour Window: A Meta . . .
    Intravenous thrombolysis (IVT) is the established treatment for ischemic stroke in eligible patients within 4 5 hours of symptom onset or patient last known well (LKW) 1 However, only a small proportion of patients are eligible and able to receive IVT within this window 2 Furthermore, there is limited evidence regarding the safety and efficacy of IVT in the extended time window (ie, beyond 4
  • A New Era of Extended Time Window Acute Stroke Interventions Guided by . . .
    Endovascular therapy decision algorithm for acute large vessel ischemic stroke Diffusion MRI Diffusion MRI is the most specific method for the early detection of the acute ischemic stroke 27–29 Diffusion MRI is the most reliable estimate of the ischemic core, which represents the irreversibly injured tissue or the “core” of the infarct 30–33 A meta-analysis found that the ischemic
  • Endovascular Therapy for Stroke Presenting Beyond 24 Hours
    Importance Previous randomized clinical trials (RCTs) have supported the use of endovascular therapy (EVT) in late-window acute ischemic stroke (AIS; 6-24 hours) However, little is known about the use of EVT in very late-window AIS (>24 hours) Objective To examine outcomes following EVT for very late-window AIS Data Sources A systematic review of the English language literature was
  • Safety and efficacy of intravenous thrombolytic therapy in the extended . . .
    However, only about 5–25% of patients are eligible for this treatment due to the narrow therapeutic window 1 One reason for exclusion is patients with an unknown onset of symptoms, which occurs in cases of wake-up or unwitnessed stroke where the symptom onset time cannot be estimated due to aphasia, impaired consciousness, or cognitive
  • Breaking Barriers in Stroke Therapy: Recent Advances and Ongoing . . .
    Mobile stroke units have expedited pre-hospital care, emphasizing the urgency of intervention under the principle "time is brain " These developments underscore the importance of timely and accurate diagnosis in improving outcomes Therapeutic breakthroughs in thrombolytic therapy and mechanical thrombectomy have transformed acute stroke treatment
  • Tissue window, not the time window, will guide acute stroke treatment
    Since the approval of intravenous (IV) tissue plasminogen activator (tPA) to treat patients with acute ischaemic stroke (AIS) within 3 hours of onset in 1996, it took 12 years to expand the treatment time window to 4 5 hours by the European Cooperative Acute Stroke Trial II (ECASS III) 1 It took another 10 years to expand the treatment time window to 6 hours with the bridging of IV tPA and
  • Randomized Clinical Trial of Extending the Time Window of . . . - PubMed
    The therapeutic time window for endovascular therapy in acute stroke patients with large-vessel occlusion was extended to 24 hours from onset Although a retrospective study showed the efficacy of endovascular therapy beyond 24 hours from the last known well, it remains unclear whether endovascular therapy is effective
  • Efficacy and Safety of Endovascular Thrombectomy for Large Vessel . . .
    Ischemic stroke is one of the leading causes of disability and death in adults worldwide 1 Achieving rapid recanalization of the occluded vessel to restore blood flow and salvage ischemic penumbral tissue is the primary therapeutic strategy to improve patient outcomes 2 Previous studies have found that the length of time from onset to reperfusion is a key factor affecting stroke prognosis
  • Tissue window, not the time window, will guide acute stroke treatment
    Since the approval of intravenous (IV) tissue plasminogen activator (tPA) to treat patients with acute ischaemic stroke (AIS) within 3 hours of onset in 1996, it took 12 years to expand the treatment time window to 4 5 hours by the European Cooperative Acute Stroke Trial II (ECASS III) 1 It took another 10 years to expand the treatment time window to 6 hours with the bridging of IV tPA and





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