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  • The Elastin Receptor Complex: An Emerging Therapeutic Target Against . . .
    The main signaling pathways mediated by the ERC and associated pharmacological inhibition strategies Bioactive EDPs binding to the ERC triggers signaling pathways that involve G αi proteins and culminate to ERK1 2 and Akt activation Increase in NEU1 sialidase activity following elastokines binding to the ERC can also modulate the sialylation level of membrane receptors at its vicinity
  • Toward a rational therapeutic for elastin related disease: Key . . .
    The process of elastin assembly may differ in the aorta compared to the lung and skin, challenging the current understanding of a uniform fiber assembly mechanism across all tissues [43] Regenerative medicine approaches aiming at depositing elastin outside of the expected developmental window may need to consider the presence and availability
  • Future of biotherapeutics: Harnessing mRNA to enhance elastin . . .
    Organs that are subjected to repeated stretching such as the skin, lungs, and vasculature rely on elasticity provided by the extracellular matrix (ECM) for structural integrity Tissue elasticity is dependent on elastic fibers composed of a protein core of insoluble elastin that is assembled onto a microfiber scaffold Tropoelastin (TE), the basic building block of elastin, is secreted as a
  • Neoelastinogenesis: Current Best Practices for Restoring and Preserving . . .
    I’ve seen a number of people talk about how vital elastin is for longevity but I had not seen much data on what we can do about it, and what treatments are on the horizon I spent my day doing a deep dive on the latest research (mostly 2024-2025) and here is what I have uncovered: Why Elastin Matters Elastin is foundational to skin firmness, vascular flexibility, lung recoil, connective
  • Emerging mechanisms of elastin transcriptional regulation
    It is deposited in a brief window starting in the prenatal period and extending to adolescence in vertebrates, and then slowly turns over Elastin insufficiency is seen in conditions such as Williams-Beuren syndrome and elastin-related supravalvar aortic stenosis, which are associated with a range of vascular and connective tissue manifestations
  • The Elastin Receptor Complex: An Emerging Therapeutic Target Against . . .
    Composition of the Elastin Receptor Complex The ERC is a heterotrimeric receptor containing a peripheral protein of 67 kDa called EBP, the protective protein cathepsin A (PPCA, 55 kDa) and the transmembrane NEU1 (61 kDa) (Figure 1) The ERC has a strong homology with the lysosomal β-galactosidase (β-gal) complex involved in the degradation of glycoconjugates wherein EBP is replaced by β-gal
  • The Elastin Receptor Complex: An Emerging Therapeutic . . . - Frontiers
    The Elastin Receptor Complex: An Emerging Therapeutic Target Against Age-Related Vascular Diseases Digneˆ Tembely 1, Aube´ri Henry , Laetitia Vanalderwiert , Kevin Toussaint1, Amar Bennasroune1,Se´bastien Blaise1, Herve´ Sartelet1, Ste´phane Jaisson1, Ce´line Gale´s2, Laurent Martiny 1, Laurent Duca1,Be´atrice Romier-Crouzet and Pascal Maurice1* 1 UMR CNRS 7369 Matrice Extracellulaire
  • Elastin-Like Polypeptides: Therapeutic Applications for an Emerging . . .
    The purpose of this review has been to describe state-of-the-art developments involving elastin-like polypeptides as a therapy-potentiating platform technology With a myriad of applications already disclosed, one can reason that these protein polymers might soon provide a succinct yet versatile means of solving real clinical challenges
  • Toward a rational therapeutic for elastin related disease: Key . . .
    Elastin is a connective tissue protein, produced from the ELN gene, that provides elasticity and recoil to tissues that stretch, such as the large arteries of the body, lung parenchyma, skin, ligaments and elastic cartilages tropoelastin, that when cross-linked … Toward a rational therapeutic for elastin related disease: Key
  • Emerging Role of Elastin-Like Polypeptides in Regenerative Medicine
    as collagen, gelatin, chitosan, fibrin, and elastin provide many benefits for regenerative therapy because of low toxicity, nonimmunogenicity, and retention of biological activity 32 Application of elastin-based materials on wound healing Role of elastin in skin regeneration Elastin is an important constituent of elastic fibers that





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