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  • Drug-Induced Acute Kidney Injury : Clinical Journal of the . . . - LWW
    Medications are a common cause of AKI, especially for patients admitted to hospital wards and the intensive care unit Although drug-related kidney injury occurs through different mechanisms, this review will focus on three specific types of tubulointerstitial injury
  • Immune Checkpoint Inhibitors and Kidney Toxicity: Advances in Diagnosis . . .
    diagnostic and predictive biomarkers of immune checkpoint inhibitor-induced acute kidney injury In the treatment section, approaches to corticosteroid use and the risks and benefits of rechallenging patients who experience acute kidney injury are debated We also clarify the long-term adverse effects of immune
  • Management of Drug-Associated Acute Interstitial Nephritis
    As early as 7 days after drug exposure, the early inflammatory lesions in AIN can begin to evolve into irreversible interstitial fibrosis This likely explains why, even with the best available management, only 40%–50% of patients with AIN experience complete renal recovery (4)
  • Treatment of acute interstitial nephritis - UpToDate
    The treatment of AIN due to drugs will be reviewed here (algorithm 1) The manifestations and diagnosis of AIN and the approach to the management of patients diagnosed with infection-induced AIN, tubulointerstitial nephritis and uveitis, kidney sarcoidosis, and AKI due to checkpoint inhibitor immunotherapy are presented separately:
  • Acute interstitial nephritis - Symptoms, diagnosis and treatment | BMJ . . .
    Acute interstitial nephritis (AIN) is caused by acute inflammation of the renal tubulo-interstitium, commonly mediated by a hypersensitivity reaction to medications Autoimmune diseases and infections are less common causes Usually drug-induced with >250 known triggering medications
  • Drug-Induced Acute Kidney Injury - cshp-scph. ca
    Trimethoprim therapy can raise SCr from baseline by 17 6-31 3% with approximately 20% decrease in CrCl but GFR does not decrease due to pseudo elevation in in SCR Most effective treatment may be managing the comorbid precipitating event i e if the patient has sepsis, treat the sepsis!
  • Immune checkpoint inhibitor-associated nephritis-treatment . . . - PubMed
    With prompt treatment initiation, most patients achieve full or partial renal recovery, allowing for re-challenge with ICI However, a subset of patients will require additional steroid-sparing therapies for corticosteroid-dependent or refractory ICI-AKI
  • A Systematic Review of Treatment for Acute Interstitial Nephritis
    Acute interstitial nephritis (AIN) is a common cause of acute kidney injury It is characterized by tubular inflammation with eosinophils histologically The mainstay treatment for AIN includes early diagnosis; underlying infection or systemic disease treatment; cessation of the offending agent; and corticosteroid therapy, when indicated





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