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  • Vitamin C biosynthesis | Learn Science at Scitable - Nature
    Like humans, other animals unable to synthesize vitamin C can always find a supply of it in other organisms that synthesize it on their own, namely plants
  • Why Don’t Humans Make Their Own Vitamin C? – CEH
    One common evolutionary theory is that some ancient prehuman ancestor lost the ability to synthesize vitamin C The evolutionary relatives of this alleged ancestor, including the higher primates (primarily chimpanzees and orangutans) and humans, inherited this mutated gene
  • Why Humans Can not Synthesize Vitamin C? The Role of GULO Pseudogene
    When our ancestors shifted their diet from meat to fruits and vegetables, vitamin C became naturally available to our bodies from external sources Therefore, it ‘intentionally’ acquired mutations to be inactive in order to control the consumption of vitamin C by our body
  • The Genetics of Vitamin C Loss in Vertebrates - PMC
    Vitamin C (ascorbic acid) plays important roles as an anti-oxidant and in collagen synthesis These important roles, and the relatively large amounts of vitamin C required daily, likely explain why most vertebrate species are able to synthesize this compound
  • Like Bats, Humans Don’t Make Their Own Vitamin C
    Now, they use rats (and bats?), but they are different from humans because they produce their own vitamin C – a critically rich antioxidant that naturally helps prevent disease The researchers wanted to uncover why this bat produced vitamin C while other bats don’t, and then compare that difference to why humans don’t produce vitamin C
  • Why Dogs Dont Need Vitamin C But Humans Do
    Their bodies can synthesize vitamin C all on their own Unlike humans, they do not need an external source To see why, let's examine the vitamin C biosynthetic pathway:
  • Why do Humans not produce Vitamin C like other mammals?
    Humans do not produce Vitamin C due to a mutation in the GULO (gulonolactone oxidase) gene, which results in the inability to synthesize the protein Normal GULO is an enzyme that catalyses the reaction of D-glucuronolactone with oxygen to L-xylo-hex-3-gulonolactone
  • Why Have Humans Lost Their Vitamin C Genes? - Frugivore Biology
    Why do humans not synthesize vitamin C, while most mammals do? To understand this apparently nonsensical evolutionary quirk, we need to know one well-kept secret: Broken vitamin C genes are unique to species with a fruit-rich diet, also called frugivores





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